Functional enrichment analysis of selected clusters by approach

The excel file of Table 15 can be downloaded by clicking here

Approach Tissue Cluster passing quality criteria Class Cluster size Term Term description Nominal p-value Hub genes mapping the term Adjusted p-value
Table 15. Functional enrichment analysis of selected clusters by approach
I VAT dark-grey Risk 103 KEGG ECM-receptor interaction 0.0086 ITGA1, CD47 0.0086
I VAT dark-grey Risk 103 KEGG D-Glutamine and D-glutamate metabolism 0.0217 GLS2 0.0217
I VAT grey60 Protection 173 KEGG Non-alcoholic fatty liver disease (NAFLD) 0.0014 LEP, NDUFA2, NDUFB8, NDUFB9, NDUFS3 0.0014
I VAT grey60 Protection 173 KEGG Insulin signaling pathway 0.0071 RHOQ, RPS6, SHC1 0.0071
I VAT light-green Risk 158 GO positive regulation of MHC class I biosynthetic process 0.0005 CIITA, NLRC5 0.0005
I VAT light-green Risk 158 KEGG Primary immunodeficiency 0.0200 TAP2, CIITA 0.0200
I VAT light-yellow Risk 149 KEGG Intestinal immune network for IgA production 0.0033 HLA-DPB1 0.0033
I VAT light-yellow Risk 149 KEGG Inflammatory bowel disease (IBD) 0.0100 HLA-DPB1 0.0100
I SMT black Risk 229 KEGG Arginine and proline metabolism 0.0019 ALDH4A1 0.0019
I SMT black Risk 229 KEGG RNA polymerase 0.0040 POLR1C, POLR2J, POLR2J2, POLR2J3 0.0040
I SMT black Risk 229 GO Proline metabolic process 0.0054 ALDH4A1 0.0054
I SMT dark-green Protection 464 KEGG Regulation of lipolysis in adipocytes 0.0135 ABHD5, FABP4, AKT3 0.0135
I SMT dark-green Protection 464 KEGG TNF signaling pathway 0.0193 RIPK1, CFLAR, MAP2K3, ATF2, CCL5 0.0193
I SMT dark-red Protection 139 GO Negative regulation of B cell differentiation 0.0004 HMGB3 0.0004
I SMT dark-red Protection 139 GO Positive regulation of macrophage differentiation 0.0043 PRKCA 0.0043
I SMT green-yellow Protection 192 GO Heterochromatin assembly 0.0002 BAHD1 0.0002
I SMT green-yellow Protection 192 GO Positive regulation of double-strand break repair via homologous recombination 0.0034 ACTR2 0.0034
I SMT green-yellow Protection 192 GO Regulation of megakaryocyte differentiation 0.0047 CNOT4, ASH2L 0.0047
I SMT green-yellow Protection 192 KEGG Hippo signaling pathway - multiple species 0.0397 LIMD1 0.0397
I SMT light-green Protection 1680 GO Synaptic vesicle to endosome fusion 0.0005 VAMP4, EEA1 0.0005
I SMT light-green Protection 1680 KEGG AGE-RAGE signaling pathway in diabetic complications 0.0214 TGFB1, FN1, PLCD1, PRKCB, SERPINE1 0.0214
I SMT purple Protection 209 KEGG Nicotinate and nicotinamide metabolism 0.0055 NAMPT 0.0055
I SMT purple Protection 209 KEGG Biosynthesis of unsaturated fatty acids 0.0312 HACD2 0.0312
II VAT brown Protection 627 GO Regulation of cell communication by electrical coupling involved in cardiac conduction 0.0001 CALM1, CALM2, CALM3, CAMK2D 0.0001
II VAT brown Protection 627 KEGG Complement and coagulation cascades 0.0020 PLG, PLAT, CFB, C3, C1R, CD59, CLU, VTN 0.0020
II VAT brown Protection 627 KEGG Glioma 0.0038 EGFR, CALM1, CALM2, CALM3, CAMK2D, MDM2, CCND1 0.0038
II VAT green Protection 447 KEGG Glycine, serine and threonine metabolism 0.0051 GCSH, GAMT, SARDH 0.0051
II VAT green Protection 447 KEGG RIG-I-like receptor signaling pathway 0.0316 DDX58, IFNA7, ATG5 0.0316
II VAT pink Risk 335 KEGG cAMP signaling pathway 0.0057 GCG, ADRB1, HTR4, SST, PTGER3, CAMK2B, GRIN2C, ATP1A3, ATP2B3, PDE4A 0.0057
II VAT pink Risk 335 KEGG Cholesterol metabolism 0.0483 ABCA1, APOE 0.0483
II VAT purple Risk 240 GO Branched-chain amino acid biosynthetic process 0.0002 BCAT1, BCAT2 0.0002
II VAT purple Risk 240 KEGG Valine. leucine and isoleucine biosynthesis 0.0008 BCAT1, BCAT2 0.0008
II VAT purple Risk 240 KEGG Linoleic acid metabolism 0.0328 PLA2G12A, CYP2J2 0.0328
II VAT yellow Risk 620 KEGG p53 signaling pathway 0.0007 CHEK1, CDK2, BAX, BBC3, TP53AIP1, APAF1, CASP9, SERPINE1, SESN1, COP1 0.0007
II VAT yellow Risk 620 KEGG Inflammatory bowel disease (IBD) 0.0450 HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-DRB5, SMAD2, GATA3 0.0450
II SMT blue Risk 947 KEGG cGMP-PKG signaling pathway 0.0060 EDNRA, ADRA2C, NFATC3, NPR2, KCNMA1, ATP1A1, ATP2A3, CNGB1, ADCY1, ADCY6, PDE2A, PDE3B, ADRB1, KCNJ8 0.0060
II SMT blue Risk 947 KEGG Regulation of lipolysis in adipocytes 0.0147 ADRB1, ADCY1, ADCY6, FABP4, PDE3B 0.0147
II SMT cyan Risk 159 GO Regulation of cytokine secretion involved in immune response 0.0002 ATG5 0.0002
II SMT cyan Risk 159 GO Transposition. RNA-mediated 0.0007 L1TD1 0.0007
II SMT grey-60 Protection 81 KEGG TGF-beta signaling pathway 0.0598 INHBB, E2F5 0.0598
II SMT grey-60 Protection 81 KEGG Fatty acid elongation 0.1023 HACD2 0.1023
II SMT magenta Risk 288 GO Positive regulation of ryanodine-sensitive calcium-release channel activity 0.0002 CALM3, CALM1, CALM2 0.0002
II SMT magenta Risk 288 KEGG Ras signaling pathway 0.0094 FGFR1, FGFR2, PDGFRA, GNG4, CALM2, CALM3, CALM1, RASA4, RASA4B 0.0094
II SMT magenta Risk 288 KEGG Complement and coagulation cascades 0.0227 F5, PROCR, C3, C1R 0.0227
II SMT purple Protection 286 KEGG Thermogenesis 0.0150 ATP5F1E, DPF3, MAP2K3, MAPK14, PRKAA2, UQCRQ, UQCR11, SMARCC1 0.0150
II SMT purple Protection 287 KEGG FoxO signaling pathway 0.0182 TGFBR2, PRKAA2, MAPK14, TNFSF10, GABARAPL1, SOD2 0.0182
II SMT purple Protection 286 KEGG Fluid shear stress and atherosclerosis 0.0193 TXN2, THBD, PRKAA2, MAP2K5, DUSP1, MAPK14 0.0193
II SMT salmon Risk 181 KEGG Pathways in cancer 0.0266 LEF1, COL4A4, BIRC7, MDM2, PRKCB, IL15, CAMK2A, NQO1, KLK3 0.0266
II SMT salmon Risk 181 KEGG Ubiquitin mediated proteolysis 0.0387 MDM2, BIRC7, FZR1 0.0387
II SMT tan Risk 234 KEGG MAPK signaling pathway 0.0021 VEGFC, TEK, RRAS2, RPS6KA2, GADD45B, TAB2, MAP3K20, MAP2K3, HSPA8, MECOM 0.0021
II SMT tan Risk 234 KEGG Endocrine and other factor-regulated calcium reabsorption 0.0359 TRPV5, ATP1A2, GNAQ 0.0359
III Inter-tissue green-yellow Risk 139 GO cGMP biosynthetic process 0.0023 NPR2, GUCY1B1 0.0023
III Inter-tissue green-yellow Risk 139 GO cGMP-mediated signaling 0.0026 CD36, NPR2, GUCY1B1 0.0026
III Inter-tissue green-yellow Risk 139 KEGG Insulin resistance 0.0123 PIK3R2, SOCS3, CD36, MLX 0.0123
III Inter-tissue green-yellow Risk 139 KEGG Adipocytokine signaling pathway 0.0196 SOCS3, CD36, RXRA 0.0196
III Inter-tissue green-yellow Risk 139 KEGG Non-alcoholic fatty liver disease (NAFLD) 0.0206 PIK3R2, RXRA, MLX 0.0206
III Inter-tissue green-yellow Risk 139 KEGG Vascular smooth muscle contraction 0.0221 KCNMA1, CALCRL, NPR2, GUCY1B1 0.0221
III Inter-tissue magenta Risk 140 GO Regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.0010 CFLAR 0.0010
III Inter-tissue magenta Risk 140 KEGG Valine. leucine and isoleucine biosynthesis 0.0282 BCAT2 0.0282
III Inter-tissue magenta Risk 140 KEGG Vasopressin-regulated water reabsorption 0.0458 CREB3L3 0.0458
III Inter-tissue skyblue-3 Protection 91 GO Positive regulation of SREBP signaling pathway 0.0045 ZBTB7B 0.0045
III Inter-tissue skyblue-3 Protection 91 GO Lipid droplet formation 0.0055 SQLE 0.0055
III Inter-tissue skyblue-3 Protection 91 KEGG Hedgehog signaling pathway 0.0281 ARRB1, SPOPL 0.0281
III Inter-tissue skyblue-3 Protection 91 KEGG MAPK signaling pathway 0.0480 PPP3CC, ARRB1, PTPN5 0.0480
III Inter-tissue tan Protection 139 GO Positive regulation of monocyte chemotaxis 0.0048 HMGB1, CCL5 0.0048
III Inter-tissue tan Protection 139 KEGG p53 signaling pathway 0.0161 CCND2, PIDD1 0.0161
III Inter-tissue tan Protection 139 KEGG Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.0285 ITGB8, ATP2A2 0.0285